9.03/9.031 Neural Basis of Learning and Memory

Reading list

• Wed 9/8:  Introduction
  • Required: Squire and Kandel, chapter 1.
  • Recommended: Martinez and Kesner, chapter 1, pp. 1-43.
• Mon 9/13 and Wed 9/15:  Non-associative learning I and II
  • Required:  Kandel and Schwartz, chapters 64 and 65, pp. 997-1032.
    Squire and Kandel, chapters 2 and 3.
  • Recommended: Martinez and Kesner, chapter 5, pp. 177-209.
  • Additional:
    Bailey, Chen, “Morphological basis of long-term habituation and sensitization in Aplysia”, Science 220:91-93 (1983).
    Castellucci, Carew, Kandel, “Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica” Science 202:1306-1308 (1978).
    Greenberg, Castellucci, Bayley, Schwartz, “A molecular mechanism for long-term sensitization in Aplysia”, Nature 329:62-65, 1987.
    Spencer, Thompson, Neilson, “Response decrement of the flexion reflex in the acute spinal cat and transient restoration by strong stimuli” J.Neurophys. 29:221-239, 1966.
• Mon 9/20: Associative learning I
  • Required:  J.DeZazzo and T.Tully, “Dissection of memory formation: from behavioral pharmacology to molecular genetics”, TINS 18:212-218 (1995).
    Squire and Kandel, chapters 3 and 7.
  • Recommended: T. Tully and W.G.Quinn, “Classical conditioning and retention in normal and mutant Drosophila melanogaster”, J. Comp. Physiol. A157:263-277 (1985).
  • Additional: M. B. Feany and W.G. Quinn, “A neuropeptide gene defined by the Drosophila memory mutant amnesiac”, Science 268:869-873 (1995).
• Wed 9/22:  Associative learning II
  • Required:
    T. V. Bliss and G. L. Collingridge, "A synaptic model of memory: long-term potentiation in the hippocampus," Nature 361:31-9 (1993).
    H. Markram et al., "Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs", Science 275:213-15 (1997).
    R. C. Malenka and R. A. Nicoll, "Long-term potentiation---a decade of progress?", Science 285:1870-74 (1999)
  • Recommended:
    Squire and Kandel, chap 6.
    Martinez and Kesner, chap 6.
• Mon 9/27 and Wed 9/29:  Classical conditioning
  • J. R. Anderson, Learning and Memory, 9-12, 39-77 (Wiley, 1995)
  • Additional:  C. R. Gallistel, The organization of learning, chapter 12 (MIT Press, 1990).
• Mon 10/4: Instrumental conditioning
  • J. R. Anderson, Learning and Memory, 78-107 (Wiley, 1995).
• Wed 10/6: Rescorla-Wagner theory
  • Barto and Sutton chapter.
• Wed 10/13 and Mon 10/18: Bee learning and basal ganglia.
  • Required:
    M. Hammer, "The neural basis of associative reward in honeybees", Trends Neurosci. 20: 245-52 (1997).
    J. Houk et al., eds, Models of information processing in the basal ganglia, chs. 2 and 12 (MIT Press, 1995).
  • Additional:
    M. Hammer, "An identified neuron mediates the unconditioned stimulus in associative olfactory learning in honeybees," Nature 366:59-63 (1993).
• Wed 10/20: Hippocampus and spatial learning I and II
  • Required:
    M. A. Wilson and S. Tonegawa, "Synaptic plasticity, place cells and spatial memory: study with second generation knockouts," Trends Neurosci. 20: 102-6 (1997).
    Muller, "A quarter century of place cells", Neuron 17:813-22 (1996).
    Eichenbaum, H.et al. "The hippocampus, memory, and place cells: is it spatial memory or a memory space", Neuron, 23:209-26, (1999).
  • Recommended:
    Wilson, M.A.,and McNaughton, B.L., "Dynamics of the hippocampal ensemble code for space," Science, 261:1055-1058, (1993).
    Wilson, M.A., and McNaughton, B.L., "Reactivation of hippocampal ensemble memories during sleep," Science, 65:676-679, (1994).
• Mon 10/25: Short-term/working memory I
  • Required:
    Miyashita, Y., "Neuronal correlate of visual associative long-term memory in the primate temporal cortex", Nature 335: 817-20 (1988).
    S. C. Rao et al., "Integration of what and where in the primate prefrontal cortex," Science 276:821-4 (1997).
    Muller, R. U., Ranck, J. B., Jr., and Taube, J. S., "Head direction cells: properties and functional significance," Curr. Opin. Neurobiol. 6:196-206 (1996).

• Mon 11/1: Short-term/working memory II
  • Baddeley, A. (1998) Recent developments in working memory. Current Opinion in Neurobiology, 8, 234-238.
    Petrides, M. (1996) Lateral frontal cortical contribution to memory. The Neurosciences, 8, 57-63.
    Owen, A.M., Evans, A.C., and Petrides, M. (1996) Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: A positron emission tomography study. Cerebral Cortex, 6, 31-38.
• Wed 11/3: Declarative memory I
  • Squire, L.R. and Kandel, E.R. (1999) Memory: From Mind to Molecules (pp. 82-107). New York: Freeman.
    Corkin, S., Amaral, D.G., Johnson, K.A., and Hyman, B.T. (1997) H.M.'s medial temporal lobe lesion: Findings from MRI. Journal of Neuroscience, 17, 3964-3979.
    Murray, E. (In Press). Memory for objects in nonhuman primates. In Gazzaniga, M., The Cognitive Neurosciences (2d. ed.). Cambridge, MA: MIT Press.
• Mon 11/8: Declarative memory II
  • Murray, E. and Bussey, T. (In Press). Perceptual-mnemonic functions of the perirhinal cortex. Trends in Cognitive Science.
    Milner, B. (1985). Memory and the human brain. In Shafto, Ed., How We Know (pp. 31-59). San Francisco: Harper & Row.
• Wed 11/10: Nondeclarative memory I
  • Squire, L.R. and Kandel, E.R. (1999) Memory: From Mind to Molecules (pp. 156-173). New York: Freeman.
    Keane, M.M., Gabrieli, J.D.E., Mapstone, H.C., Johnson, K.A., and Corkin, S. (1995) Double dissociation of memory capacities after bilateral occipital-lobe or medial temporal-lobe lesions. Brain, 118, 1129-1148.
• Mon 11/15: Nondeclarative memory II
  • Squire, L.R. and Kandel, E.R. (1999) Memory: From Mind to Molecules (pp. 174-193). New York: Freeman.
    Shadmehr, R., Brandt, J., and Corkin, S. (1998) Time-dependent motor memory processes in amnesic subjects. Journal of Neurophysiology, 80, 1590-1597.
• Wed 11/17: Neural networks I
  • Hertz, Krogh, and Palmer, Introduction to the theory of neural computation, pp. 89-100 (Addison-Wesley, 1991).
• Mon 11/22: Neural networks II
  • Required: J. Hopfield, "Neural networks and physical systems with emergent collective computational abilities." Proc. Natl. Acad. Sci. USA. 79:2554-8 (1982).
  • Additional:  Hertz, Krogh, and Palmer, Introduction to the theory of neural computation, pp. 11-25 (Addison-Wesley, 1991).
• Mon 11/22: Neural networks III
  • Recommended:  Seung, H. S., "How the brain keeps the eyes still", PNAS 93:13339-44 (1996).
• Mon 11/29: Birdsong (ignore this...the lecture was cancelled)
  • Required:
    Mooney, R. "Sensitive periods and circuits for learned birdsong", Curr Opin Neurobiol 9:121-7, (1999).
    Doupe, A.J. "A neural circuit specialized for vocal learning", Curr Opin Neurobiol, 3:104-11 (1993).
  • Recommended:
    Ball, G.F., Hulse, S.H. "Birdsong", Am Psychol, 53:37-58, (1998).
    Doupe, A.J.,` Solis. M.M. "Song and order selective neurons develop in the songbird anterior forebrain during vocal learning", J. Neurobiol. 33:694-709, (1997).
    Mooney, R. "Behavioral learning. The illuminated songbird", Curr Biol 5:609-11, (1995).
  • Additional:
    Saito, N., Maekawa, M. "Birdsong: the interface with human language", Brain Dev, 15:31-9, (1993).
    Clayton, D.F. "Role of gene regulation in song circuit development and song learning", J. Neurobiol 33:549-71, (1997).
• Wed 12/1: Cortical maps I (Corkin/Moore)
  • Melzack, R. (1992) Phantom limbs. Scientific American, ###, 120-126.
    Yang, T.T., Gallen, C.C., Ramachandran, V.V., Cobb, S., Schwartz, B.J., and Bloom, F.E. (1994) Noninvasive detection of cerebral plasticity in adult human somatosensory cortex. NeuroReport, 5, 701-704.
    Pons, T.P., Garraghty, P.E., Ommaya, A.K., Kaas, J.H., Taub, E., Mishkin, M. Massive cortical reorganization after sensory deafferentation in adult macaques. Science, 252, 1857-1860.
    Merzenich, M.M., and Sameshima, K (1983) Cortical plasticity and memory. Current Opinion in Neurobiology, 3, 187-196.
• Mon 12/6: Cortical maps II (Seung)
  • Kandel and Schwartz, Chapter 60
  • Additional:  D. H. Hubel, Eye, brain and vision, Chapter 9 (New York: Freeman, 1988).
• Wed 12/8: Review