9.03/9.031 Neural Basis of Learning and Memory
- Wed 9/8: Introduction
- Required: Squire and Kandel, chapter 1.
- Recommended: Martinez and Kesner, chapter 1, pp. 1-43.
- Mon 9/13 and Wed 9/15: Non-associative learning I and II
- Required: Kandel and Schwartz, chapters 64 and 65, pp. 997-1032.
Squire and Kandel, chapters 2 and 3.
- Recommended: Martinez and Kesner, chapter 5, pp. 177-209.
Bailey, Chen, Morphological
basis of long-term habituation and sensitization in Aplysia, Science
Castellucci, Carew, Kandel, Cellular
analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica
Science 202:1306-1308 (1978).
Greenberg, Castellucci, Bayley, Schwartz, A
molecular mechanism for long-term sensitization in Aplysia, Nature
Spencer, Thompson, Neilson, Response decrement of the flexion reflex in the acute
spinal cat and transient restoration by strong stimuli J.Neurophys.
- Mon 9/20: Associative learning I
- Wed 9/22: Associative learning II
T. V. Bliss and G. L. Collingridge, "A synaptic model of memory: long-term
potentiation in the hippocampus," Nature 361:31-9 (1993).
H. Markram et al., "Regulation of synaptic efficacy by coincidence of postsynaptic
APs and EPSPs", Science 275:213-15 (1997).
R. C. Malenka and R. A. Nicoll, "Long-term potentiation---a decade of
progress?", Science 285:1870-74 (1999)
Squire and Kandel, chap 6.
Martinez and Kesner, chap 6.
- Mon 9/27 and Wed 9/29: Classical conditioning
- J. R. Anderson, Learning and Memory, 9-12, 39-77 (Wiley, 1995)
- Additional: C. R. Gallistel, The organization of learning, chapter 12
(MIT Press, 1990).
- Mon 10/4: Instrumental conditioning
- J. R. Anderson, Learning and Memory, 78-107 (Wiley, 1995).
- Wed 10/6: Rescorla-Wagner theory
- Barto and Sutton chapter.
- Wed 10/13 and Mon 10/18: Bee learning and basal ganglia.
M. Hammer, "The neural basis of associative reward in honeybees", Trends
Neurosci. 20: 245-52 (1997).
J. Houk et al., eds, Models of information processing in the basal ganglia, chs.
2 and 12 (MIT Press, 1995).
M. Hammer, "An identified neuron mediates the unconditioned stimulus in associative
olfactory learning in honeybees," Nature 366:59-63 (1993).
- Wed 10/20: Hippocampus and spatial learning I and II
M. A. Wilson and S. Tonegawa, "Synaptic plasticity, place cells and spatial memory:
study with second generation knockouts," Trends Neurosci. 20: 102-6 (1997).
Muller, "A quarter century of place cells", Neuron 17:813-22 (1996).
Eichenbaum, H.et al. "The hippocampus, memory, and place cells: is it spatial memory
or a memory space", Neuron, 23:209-26, (1999).
Wilson, M.A.,and McNaughton, B.L., "Dynamics of the hippocampal ensemble code for
space," Science, 261:1055-1058, (1993).
Wilson, M.A., and McNaughton, B.L., "Reactivation of hippocampal ensemble memories
during sleep," Science, 65:676-679, (1994).
- Mon 10/25: Short-term/working memory I
Miyashita, Y., "Neuronal correlate of visual associative long-term memory in the
primate temporal cortex", Nature 335: 817-20 (1988).
S. C. Rao et al., "Integration of what and where in the primate prefrontal
cortex," Science 276:821-4 (1997).
Muller, R. U., Ranck, J. B., Jr., and Taube, J. S., "Head direction cells: properties
and functional significance," Curr. Opin. Neurobiol. 6:196-206 (1996).
- Mon 11/1: Short-term/working memory II
- Baddeley, A. (1998) Recent developments in working memory. Current Opinion in
Neurobiology, 8, 234-238.
Petrides, M. (1996) Lateral frontal cortical contribution to memory. The Neurosciences, 8,
Owen, A.M., Evans, A.C., and Petrides, M. (1996) Evidence for a two-stage model of spatial
working memory processing within the lateral frontal cortex: A positron emission
tomography study. Cerebral Cortex, 6, 31-38.
- Wed 11/3: Declarative memory I
- Squire, L.R. and Kandel, E.R. (1999) Memory: From Mind to Molecules (pp. 82-107). New
Corkin, S., Amaral, D.G., Johnson, K.A., and Hyman, B.T. (1997) H.M.'s medial temporal
lobe lesion: Findings from MRI. Journal of Neuroscience, 17, 3964-3979.
Murray, E. (In Press). Memory for objects in nonhuman primates. In Gazzaniga, M., The
Cognitive Neurosciences (2d. ed.). Cambridge, MA: MIT Press.
- Mon 11/8: Declarative memory II
- Murray, E. and Bussey, T. (In Press). Perceptual-mnemonic functions of the perirhinal
cortex. Trends in Cognitive Science.
Milner, B. (1985). Memory and the human brain. In Shafto, Ed., How We Know (pp. 31-59).
San Francisco: Harper & Row.
- Wed 11/10: Nondeclarative memory I
- Squire, L.R. and Kandel, E.R. (1999) Memory: From Mind to Molecules (pp. 156-173). New
Keane, M.M., Gabrieli, J.D.E., Mapstone, H.C., Johnson, K.A., and Corkin, S. (1995) Double
dissociation of memory capacities after bilateral occipital-lobe or medial temporal-lobe
lesions. Brain, 118, 1129-1148.
- Mon 11/15: Nondeclarative memory II
- Squire, L.R. and Kandel, E.R. (1999) Memory: From Mind to Molecules (pp. 174-193). New
Shadmehr, R., Brandt, J., and Corkin, S. (1998) Time-dependent motor memory processes in
amnesic subjects. Journal of Neurophysiology, 80, 1590-1597.
- Wed 11/17: Neural networks I
- Hertz, Krogh, and Palmer, Introduction to the theory of neural computation, pp. 89-100
- Mon 11/22: Neural networks II
- Mon 11/22: Neural networks III
- Recommended: Seung, H. S., "How the brain keeps the eyes still", PNAS
- Mon 11/29: Birdsong (ignore this...the lecture was cancelled)
Mooney, R. "Sensitive periods and circuits for learned birdsong", Curr Opin
Neurobiol 9:121-7, (1999).
Doupe, A.J. "A neural circuit specialized for vocal learning", Curr Opin
Neurobiol, 3:104-11 (1993).
Ball, G.F., Hulse, S.H. "Birdsong", Am Psychol, 53:37-58, (1998).
Doupe, A.J.,` Solis. M.M. "Song and order selective neurons develop in the songbird
anterior forebrain during vocal learning", J. Neurobiol. 33:694-709, (1997).
Mooney, R. "Behavioral learning. The illuminated songbird", Curr Biol 5:609-11,
Saito, N., Maekawa, M. "Birdsong: the interface with human language", Brain Dev,
Clayton, D.F. "Role of gene regulation in song circuit development and song
learning", J. Neurobiol 33:549-71, (1997).
- Wed 12/1: Cortical maps I (Corkin/Moore)
- Melzack, R. (1992) Phantom limbs. Scientific American, ###, 120-126.
Yang, T.T., Gallen, C.C., Ramachandran, V.V., Cobb, S., Schwartz, B.J., and Bloom, F.E.
(1994) Noninvasive detection of cerebral plasticity in adult human somatosensory cortex.
NeuroReport, 5, 701-704.
Pons, T.P., Garraghty, P.E., Ommaya, A.K., Kaas, J.H., Taub, E., Mishkin, M. Massive
cortical reorganization after sensory deafferentation in adult macaques. Science, 252,
Merzenich, M.M., and Sameshima, K (1983) Cortical plasticity and memory. Current Opinion
in Neurobiology, 3, 187-196.
- Mon 12/6: Cortical maps II (Seung)
- Kandel and Schwartz, Chapter 60
- Additional: D. H. Hubel, Eye, brain and vision, Chapter 9 (New York:
- Wed 12/8: Review