Table of Contents
Long-term potentiation
Aristotle (350 BC)
William James (1892)
Donald Hebb (1949)
Long-term memory
Synaptic plasticity
Readings
Hippocampus
Frontal section of human brain
Three principal pathways
Perforant pathway LTP (in vivo)
Schaffer collateral LTP (in vitro)
Basis of classical conditioning?
Synaptic plasticity
Induction: the players
Glutamate receptors
Magnesium block
AP5 is a selective blocker
Calcium imaging
Dendritic spines
Calcium transients in spines
Model for LTP induction
Explanation of LTP properties
Elaborations of induction model
LTP vs. other types of plasticity
LTP phases
LTP1 mechanisms: pre or post?
Protein kinases
AMPA receptor changes
“Post-” model for expression
Quantal analysis
Retrograde messenger
LTP in cortical pyramidal cells
LTP requires pairing
AP/EPSP pairing
Dependence on spike timing
Hippocampal LTP and LTD
Summary
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