Modeling the neural basis of learning and memory

11/22/99


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Table of Contents

Modeling the neural basis of learning and memory

Behavior . . .

. . . and its neural basis

Head direction neurons

The “astonishing hypothesis”

Computational neuroscience

The neuron doctrine

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Microelectrode recording

Neurons are polarized and excitable

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Biophysics of neurons

Ion channels are membrane proteins

Channels are selectively permeable

Channels are gated or nongated

The Nernst equation

Charge separation

Membrane capacitance

Ohmic model

Cable theory

Biophysics of neurons

Hodgkin-Huxley model

Statics of several ionic species

Hodgkin-Huxley equations

Channel variables

Patch clamp recording

Single ion channel

Hodgkin-Huxley equations

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Intrinsically bursting neuron

Biophysics of neurons

Synapses

Chemical synapse

Synaptic transmission

Transmission is stochastic

Neurotransmitters

Ionotropic vs. metabotropic action

Synaptic activation

Biophysics of neurons

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Author: Sebastian Seung